In this article, we will discuss Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid. So, let’s get started.
Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid
A total of 64 Mycophenolate-treated renal transplant recipients received either oral ciprofloxacin 500 mg bid or amoxicillin plus clavulanic acid 375 mg tid for 7 or at least
14 days. Approximately 50% reductions in median trough MPA concentrations (pre-
dose) from baseline (Mycophenolate alone) were observed in 3 days following commencement of oral ciprofloxacin or amoxicillin plus clavulanic acid. These reductions in trough MPA concentrations tended to diminish within 14 days of antibiotic therapy and ceased within 3 days after discontinuation of antibiotics. The postulated mechanism for this interaction is an antibiotic-induced reduction in glucuronidase-possessing enteric organisms leading to a decrease in enterohepatic recirculation of MPA. The change in trough level may not accurately represent changes in overall MPA exposure; therefore, clinical relevance of these observations is unclear.