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Disease Modifying Anti-rheumatic Drugs,DMARDs Mycophenolate Pharmacology Physiotherapy

Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid

In this article we will discuss Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid

In this article, we will discuss Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid. So, let’s get started.

Mycophenolate and Ciprofloxacin and Amoxicillin plus Clavulanic Acid

A total of 64 Mycophenolate-treated renal transplant recipients received either oral ciprofloxacin 500 mg bid or amoxicillin plus clavulanic acid 375 mg tid for 7 or at least
14 days. Approximately 50% reductions in median trough MPA concentrations (pre-
dose) from baseline (Mycophenolate alone) were observed in 3 days following commencement of oral ciprofloxacin or amoxicillin plus clavulanic acid. These reductions in trough MPA concentrations tended to diminish within 14 days of antibiotic therapy and ceased within 3 days after discontinuation of antibiotics. The postulated mechanism for this interaction is an antibiotic-induced reduction in glucuronidase-possessing enteric organisms leading to a decrease in enterohepatic recirculation of MPA. The change in trough level may not accurately represent changes in overall MPA exposure; therefore, clinical relevance of these observations is unclear.

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