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Disease Modifying Anti-rheumatic Drugs,DMARDs Mycophenolate Pharmacology Physiotherapy

Mycophenolate and Norfloxacin and Metronidazole

In this article we will discuss Mycophenolate and Norfloxacin and Metronidazole

In this article, we will discuss Mycophenolate and Norfloxacin and Metronidazole. So, let’s get started.

Mycophenolate and Norfloxacin and Metronidazole

Following single-dose administration of mycophenolate mofetil (1 g) to 11 healthy
volunteers on day 4 of a 5 day course of a combination of norfloxacin and metronidazole, the mean MPA AUC0-48h was significantly reduced by 33% compared to the administration of mycophenolate mofetil alone (p<0.05). Therefore, mycophenolate is not recommended to be given with the combination of norfloxacin and metronidazole. There was no significant effect on mean MPA AUC0-48h when mycophenolate mofetil was
concomitantly administered with norfloxacin or metronidazole separately. The mean (±SD) MPA AUC0-48h after coadministration of mycophenolate mofetil with norfloxacin or metronidazole separately was 48.3 (±24) μg·h/mL and 42.7 (±23) μg·h/mL, respectively, compared with 56.2 (±24) μg·h/mL after administration of mycophenolate mofetil alone.

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