In this article, we will discuss Mycophenolate and Trimethoprim/sulfamethoxazole. So, let’s get started.
Mycophenolate and Trimethoprim/sulfamethoxazole
Following single-dose administration of mycophenolate mofetil (1.5 g) to 12 healthy
male volunteers on day 8 of a 10 day course of trimethoprim 160 mg/sulfamethoxazole
800 mg administered bid, no effect on the bioavailability of MPA was observed. The
mean (±SD) AUC and Cmax of MPA after concomitant administration were 75.2 (±19.8) μg•h/mL and 34.0 (±6.6) μg/mL, respectively, compared to 79.2 (±27.9) μg•h/mL and 34.2 (±10.7) μg/mL, respectively, after administration of mycophenolate mofetil alone.