Sotorasib and Carcinogenesis

In this article, we will discuss Sotorasib and Carcinogenesis. So, let’s get started.

Carcinogenesis

  • Carcinogenicity studies have not been performed with sotorasib.
  • Sotorasib was not mutagenic in an in vitro bacterial reverse mutation (Ames) assay and was not genotoxic in the in vivo rat micronucleus and comet assays.
  • Fertility/early embryonic development studies were not conducted with sotorasib. There were no adverse effects on female or male reproductive organs in general toxicology studies conducted in dogs and rats.

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