In this article, we will discuss Trametinib and Hyperglycemia. So, let’s get started.
Trametinib and Hyperglycemia
In the COMBI-d study, 27% of patients with a history of diabetes who received Trametinib and dabrafenib required more intensive hypoglycemic therapy. Grade 3 and Grade 4 hyperglycemia based on laboratory values
occurred in 5% and 0.5% of patients receiving Trametinib and dabrafenib, respectively. Monitor serum glucose levels upon initiation and as clinically appropriate when Trametinib is administered with dabrafenib in patients with pre-existing diabetes or hyperglycemia. Initiate or optimize anti-hyperglycemic
medications as clinically indicated.