Emapalumab-lzsg (Mechanism of Action)

In this article, we will discuss Emapalumab-lzsg (Mechanism of Action). So, let’s get started.

Mechanism of Action

Emapalumab-lzsg is a monoclonal antibody that binds to and neutralizes interferon gamma (IFNγ). Nonclinical data suggest that IFNγ plays a pivotal role in the pathogenesis of HLH by being hypersecreted.

Pharmacodynamics

IFNγ Inhibition
Emapalumab-lzsg reduces the plasma concentrations of CXCL9, a chemokine induced by IFNγ.

Cardiac Electrophysiology
At a dose of 3 mg/kg GAMIFANT does not prolong the QT interval to any clinically relevant extent.

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