In this article, we will discuss Emapalumab-lzsg (Mechanism of Action). So, let’s get started.
Mechanism of Action
Emapalumab-lzsg is a monoclonal antibody that binds to and neutralizes interferon gamma (IFNγ). Nonclinical data suggest that IFNγ plays a pivotal role in the pathogenesis of HLH by being hypersecreted.
Pharmacodynamics
IFNγ Inhibition
Emapalumab-lzsg reduces the plasma concentrations of CXCL9, a chemokine induced by IFNγ.
Cardiac Electrophysiology
At a dose of 3 mg/kg GAMIFANT does not prolong the QT interval to any clinically relevant extent.