Palifermin (Pharmacodynamics)

In this article, we will discuss Palifermin (Pharmacodynamics). So, let’s get started.

Pharmacodynamics

Epithelial cell proliferation was assessed by Ki67 immunohistochemical staining in
healthy subjects. A 3-fold or greater increase in Ki67 staining was observed in buccal
biopsies from 3 of 6 healthy subjects given Palifermin at 40 mcg/kg/day IV for 3 days,
when measured 24 hours after the third dose. Dose-dependent epithelial cell proliferation was observed in healthy subjects given single IV doses of 120 to 250 mcg/kg 48 hours post-dosing.

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