Anticancer Drugs Oncology Palifermin Pharmacology Physiotherapy

Palifermin (Pharmacodynamics)

In this article we will discuss Palifermin (Pharmacodynamics)

In this article, we will discuss Palifermin (Pharmacodynamics). So, let’s get started.


Epithelial cell proliferation was assessed by Ki67 immunohistochemical staining in
healthy subjects. A 3-fold or greater increase in Ki67 staining was observed in buccal
biopsies from 3 of 6 healthy subjects given Palifermin at 40 mcg/kg/day IV for 3 days,
when measured 24 hours after the third dose. Dose-dependent epithelial cell proliferation was observed in healthy subjects given single IV doses of 120 to 250 mcg/kg 48 hours post-dosing.

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