In this article, we will discuss Fedratinib (Dosage Overview). So, let’s get started.
Fedratinib is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis (MF).
Conduct baseline testing of thiamine (Vitamin B1) levels prior to initiation of fedratinib.
The recommended dosage of fedratinib is 400 mg taken orally once daily for patients with a baseline platelet count of greater than or equal to 50 x 109/L.
Fedratinib may be taken with or without food. Administration with a high fat meal may reduce the incidence of nausea and vomiting.
Modify the dose for patients using concomitant strong CYP3A4 inhibitors, and in patients with severe renal impairment (creatinine clearance (CLcr) 15 mL/min to 29 mL/min).
If a dose of Fedratinib is missed, the next scheduled dose should be taken the following day. Patients that are on treatment with ruxolitinib before the initiation of Fedratinib must taper and discontinue according to the ruxolitinib prescribing information.