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Anticancer Drugs Asciminib Medicine Oncology Pharmacology Physiotherapy

Asciminib

In this article we will discuss Asciminib (Dosage Overview)

In this article, we will discuss Asciminib (Dosage Overview). So, let’s get started.

Indications

Asciminib is indicated for the treatment of adult patients with:
• Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with two or more tyrosine kinase inhibitors (TKIs).
• Ph+ CML in CP with the T315I mutation.

Dosage

Recommended Dosage in Patients with Ph+ CML-CP, Previously Treated with Two or More TKIs

The recommended dose of Asciminib is 80 mg taken orally once daily at approximately the same time each day or 40 mg twice daily at approximately 12-hour intervals. The recommended dose of Asciminib is taken orally without food.
Avoid food consumption for at least 2 hours before and 1 hour after taking Asciminib.
Continue treatment with Asciminib as long as clinical benefit is observed or until unacceptable toxicity occurs.

Recommended Dosage in Patients with Ph+ CML-CP with the T315I Mutation

The recommended dose of Asciminib is 200 mg taken orally twice daily at approximately 12-hour intervals. The recommended dose of Asciminib is taken orally without food. Avoid food consumption for at least 2 hours before and 1 hour after taking Asciminib.

Missed Dose

Once Daily Dosage Regimen: If a Asciminib dose is missed by more than approximately 12 hours, skip the dose and take the next dose as scheduled.
Twice Daily Dosage Regimens: If a Asciminib dose is missed by more than approximately 6 hours, skip the dose and take the next dose as scheduled.

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