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Anticancer Drugs Medicine Oncology Pharmacology Physiotherapy Trabectedin

Trabectedin (Mechanism of Action)

In this article we will discuss Trabectedin (Mechanism of Action)

In this article, we will discuss Trabectedin (Mechanism of Action). So, let’s get started.

Mechanism of Action

Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, forming adducts and resulting in a bending of the DNA helix towards the major groove. Adduct formation triggers a cascade of events that can affect the subsequent activity of DNA binding proteins, including some transcription factors, and DNA repair pathways, resulting in perturbation of the cell cycle and eventual cell death.

Pharmacodynamics

Cardiac Electrophysiology
The effect of trabectedin on the QT/QTc interval was evaluated in 75 patients who received placebo on day 1 and trabectedin (1.3 mg/m²) as a 3-hour intravenous infusion on day 2. No patients in the study showed a QTc interval exceeding 500 msec or more than 60 msec increase from baseline, and no large changes in the mean QTc interval (i.e., >20 msec) were observed.

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