Denileukin Diftitox

In this article, we will discuss Denileukin Diftitox (Dosage Overview). So, let’s get started.

Indications

Denileukin diftitox is indicated for the treatment of patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor.

Dosage

Dosing Schedule and Administration
• Premedicate with an antihistamine and acetaminophen prior to each Ontak infusion.
• Administer at 9 or 18 mcg/kg/day by intravenous infusion over 30-60 minutes for 5 consecutive days every 21 days for 8 cycles.
• Do not administer as a bolus injection.
• Withhold administration of Ontak if serum albumin levels are less than 3.0 g/dL.
• Discontinue for adverse infusion reactions.

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