In this article, we will discuss Nelarabine (Dosage Overview). So, let’s get started.
Indications
Nelarabine is indicated for the treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. This use is based on the induction of complete responses. Randomized trials demonstrating increased survival or other clinical benefit have not been conducted.
Dosage
Recommended Dosage
This product is for intravenous use only.
The recommended duration of treatment for adult and pediatric patients has not been clearly established. In clinical trials, treatment was generally continued until there was evidence of disease progression, the patient experienced unacceptable toxicity, the patient became a candidate for bone marrow transplant, or the patient no longer continued to benefit from treatment.
Adult Dosage: The recommended adult dose of nelarabine is 1,500 mg/m² administered intravenously over 2 hours on days 1, 3, and 5 repeated every 21 days. Nelarabine is administered undiluted.
Pediatric Dosage: The recommended pediatric dose of nelarabine is 650 mg/m² administered intravenously over 1 hour daily for 5 consecutive days repeated every 21 days. nelarabine is administered undiluted.