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Anticancer Drugs Oncology Palifermin Pharmacology Physiotherapy

Palifermin

In this article we will discuss Palifermin (Dosage Overview)

In this article, we will discuss Palifermin (Dosage Overview). So, let’s get started.

Indications

Palifermin is a mucocutaneous epithelial human growth factor indicated to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of autologous hematopoietic stem cell support. Palifermin is indicated as supportive care for preparative regimens predicted to result in ≥ WHO Grade 3 mucositis in the majority of patients.

Limitations of Use
The safety and efficacy of Palifermin have not been established in patients with non-hematologic malignancies.

Palifermin was not effective in decreasing the incidence of severe mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of allogeneic hematopoietic stem cell support.

Palifermin is not recommended for use with melphalan 200 mg/m2 as a conditioning regimen.

Dosage

Recommended Dosage Regimen
The recommended dose of palifermin is 60 mcg/kg/day, administered as an intravenous bolus injection for 3 consecutive days before and 3 consecutive days after myelotoxic therapy, for a total of 6 doses. Administer the first 3 doses prior to myelotoxic therapy. Administer the third dose 24 to 48 hours prior to beginning myelotoxic therapy.

Administer the last 3 doses after myelotoxic therapy is complete; Administer the first of these doses on the day of hematopoietic stem cell infusion after the infusion is completed, and at least 7 days after the most recent administration of Kepivance.

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