Anticancer Drugs Defibrotide Sodium Oncology Pharmacology Physiotherapy

Defibrotide Sodium

In this article we will discuss Defibrotide Sodium (Dosage Overview)

In this article, we will discuss Defibrotide Sodium (Dosage Overview). So, let’s get started.


Defibrotide Sodium is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).


Recommended Dosage

The recommended dosage of Defibrotide Sodium for adult and pediatric patients is 6.25 mg/kg every 6 hours given as a 2-hour intravenous infusion. The dose should be based on patient’s baseline body weight, defined as the patient’s weight prior to the preparative regimen for HSCT.

Administer Defibrotide Sodium for a minimum of 21 days. If after 21 days signs and symptoms of hepatic VOD have not resolved, continue Defibrotide Sodium until resolution of VOD or up to a maximum of 60 days.

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