Granisetron

In this article, we will discuss Granisetron (Dosage Overview). So, let’s get started.

Indications

Granisetron hydrochloride tablets USP are indicated for the prevention of:

• Nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.
• Nausea and vomiting associated with radiation, including total body irradiation and fractionated abdominal radiation.

Dosage

Emetogenic Chemotherapy

The recommended adult dosage of oral granisetron hydrochloride tablets USP is 2 mg once daily or 1 mg twice daily. In the 2 mg once-daily regimen, two 1 mg tablets are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet is given up to 1 hour before chemotherapy, and the second tablet, 12 hours after the first. Either regimen is administered only on the day(s) chemotherapy is given. Continued treatment, while not on chemotherapy, has not been found to be useful.

Radiation (Either Total Body Irradiation or Fractionated Abdominal Radiation)

The recommended adult dosage of oral granisetron hydrochloride tablets USP is 2 mg once daily. Two 1 mg tablets are taken within 1 hour of radiation.