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Anticancer Drugs Oncology Pharmacology Physiotherapy

Oxaliplatin (Dosage)

In this article we will discuss Oxaliplatin (Dosage Overview)

In this article, we will discuss Oxaliplatin (Dosage Overview). So, let’s get started.

Indications

Oxaliplatin is a platinum-based drug used in combination with infusional 5­
fluorouracil /leucovorin, which is indicated for:
• adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.
• treatment of advanced colorectal cancer.

Dosage

• Administer Oxaliplatin in combination with 5-fluorouracil/leucovorin every 2 weeks.
− Day 1: Oxaliplatin 85 mg/m² intravenous infusion in 250-500 mL 5% Dextrose Injection, USPand leucovorin 200 mg/m² intravenous infusion in 5% Dextrose Injection, USP both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-fluorouracil 400
mg/m² intravenous bolus given over 2-4 minutes, followed by 5­ fluorouracil 600 mg/m² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.
− Day 2: leucovorin 200 mg/m²
intravenous infusion over 120 minutes,
followed by 5-fluorouracil 400 mg/m²
IV bolus given over 2-4 minutes, followed by 5-fluorouracil 600 mg/m² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.
• Reduce the dose of Oxaliplatin to 75 mg/m² (adjuvant setting) or 65 mg/m² (advanced colorectal cancer):
− if there are persistent grade 2 neurosensory events that do not resolve

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