Nilotinib (Side Effects)

In this article, we will discuss Nilotinib (Side Effects). So, let’s get started.

Adverse Reactions

The following clinically significant adverse reactions can occur with Nilotinib (Tasigna®) and are discussed below:

• Myelosuppression
• QT Prolongation
• Sudden Deaths
• Cardiac and Arterial Vascular Occlusive Events
• Pancreatitis and Elevated Serum Lipase
• Hepatotoxicity
• Electrolyte Abnormalities
• Hemorrhage
• Fluid Retention

Warnings and Precautions

Myelosuppression: Monitor complete blood count (CBC) during therapy and manage by treatment interruption or dose reduction.
Cardiac and Arterial Vascular Occlusive Events: Evaluate cardiovascular status, monitor and manage cardiovascular risk factors during Nilotinib (Tasigna®) therapy.
Pancreatitis and Elevated Serum Lipase: Monitor serum lipase, if elevations are accompanied by abdominal symptoms, interrupt doses and consider appropriate diagnostics to exclude pancreatitis.
Hepatotoxicity: Monitor hepatic function tests monthly or as clinically indicated.
Electrolyte Abnormalities: Nilotinib (Tasigna®) can cause hypophosphatemia, hypokalemia, hyperkalemia, hypocalcemia, and hyponatremia. Correct electrolyte abnormalities prior to initiating Nilotinib (Tasigna®) and monitor periodically during therapy.
Tumor Lysis Syndrome: Maintain adequate hydration and correct uric acid levels prior to initiating therapy with Nilotinib (Tasigna®).
Hemorrhage: Hemorrhage from any site may occur. Advise patients to report signs and symptoms of bleeding and medically manage as needed.
Fluid Retention: Monitor patients for unexpected rapid weight gain, swelling, and shortness of breath. Manage medically.
Effects on Growth and Development in Pediatric Patients: Growth retardation has been reported in pediatric patients treated with Nilotinib (Tasigna®). Monitor growth and development in pediatric patients.
Embryo-Fetal Toxicity: Advise patients of potential risk to a fetus and to use effective contraception.
Treatment Discontinuation: Patients must have typical BCR-ABL transcripts. An FDA-authorized test with a detecuon limit below MR4.5 must be used to determine eligibility for discontinuation. Patients must be frequently monitored by the FDA authorized test to detect possible loss of remission.

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