Enzalutamide

In this article, we will discuss about Enzalutamide (Dosage Overview). So, let’s get started.

Indications

Enzalutamide (XTANDI®) is indicated for the treatment of patients with:
• castration-resistant prostate cancer (CRPC)
• metastatic castration-sensitive prostate cancer (mCSPC).

Dosage

Dosing Information

The recommended dose of Enzalutamide (XTANDI®) is 160 mg (four 40 mg capsules) administered orally once daily. Enzalutamide (XTANDI®) can be taken with or without food.

Dose Modifications

If a patient experiences a ≥Grade 3 toxicity or an intolerable side effect, withhold dosing for one week or until symptoms improve to ≤ Grade 2, then resume at the same or a reduced dose (120 mg or 80 mg), if warranted.

Concomitant Strong CYP2C8 Inhibitors

The concomitant use of strong CYP2C8 inhibitors should be avoided if possible. If patients must be co-administered a strong CYP2C8 inhibitor, reduce the Enzalutamide (XTANDI®) dose to 80 mg once daily. If co-administration of the strong inhibitor is discontinued, the Enzalutamide (XTANDI®) dose should be returned to the dose used prior to initiation of the strong CYP2C8 inhibitor.

Concomitant Strong CYP3A4 Inducers

The concomitant use of strong CYP3A4 inducers should be avoided if possible. If patients must be co-administered a strong CYP3A4 inducer, increase the Enzalutamide (XTANDI®) dose from 160 mg to 240 mg once daily. If co-administration of the strong CYP3A4 inducer is discontinued, the Enzalutamide (XTANDI®) dose should be returned to the dose used prior to initiation of the strong CYP3A4 inducer.

Adverse Reactions

The most common adverse reactions & 10%) that occurred more frequently
≥ 2% over placebo) in the Enzalutamide (XTANDI®)-treated patients are asthenia, fatigue, back pain, hot flush, constipation, arthralgia, decreased appetite. diarrhea, and hypertension.

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