In this article, we will discuss about Haloperidol (Dosage Overview). So, let’s get started.
Mechanism of Action
HALDOL Decanoate 50 and HALDOL Decanoate 100 are the long-acting forms of HALDOL (haloperidol). The basic effects of haloperidol decanoate are no different from those of HALDOL with the exception of duration of action. Haloperidol blocks the effects of dopamine and increases its turnover rate; however, the precise mechanism of action is unknown.
Administration of haloperidol decanoate in sesame oil results in slow and sustained release of haloperidol. The plasma concentrations of haloperidol gradually rise, reaching a peak at about 6 days after the injection, and falling thereafter, with an apparent half-life of about 3 weeks. Steady state plasma concentrations are achieved after the third or fourth dose. The relationship between dose of haloperidol decanoate and plasma haloperidol concentration is roughly linear for doses below 450 mg. It should be noted, however, that the pharmacokinetics of haloperidol decanoate following intramuscular injections can be quite variable between subjects.
Haloperidol Autism spectrum disorder: 0.025-0.05 mg/kg/d; Psychotic disorder: 0.05-0.15 mg/kg/d q 8-12 hr; Nonpsychotic behavior disorder: 0.05-0.075 mg/kg/d; Agitation/hyperkinesia (chorea): 0.01-0.03 mg/kg/d q 8-12 hr; Gilles de la Tourette syndrome: 0.05-0.075 mg/kg/day in 2-3 divided doses.
Adult dose: Anxiety: 0.5 mg BID, antipsychotic: 0.5-5.0 mg 2–3 doses/d (maximum 30 mg/d).
Side Effects: Extrapyramidal and acute oculogyric effects similar to those with phenothiazines are observed and can be reversed with benztropine and diphenhydramine.
(Halopidol tabs 2 mg, 5 mg, 10 mg, 20 mg, depidol tabs 0.25 mg, 1.5 mg, 5 mg and 10 mg; depidol, halidol tabs 0.25 mg, 1.5 mg; serenace tabs 0.25, 1.5, 5 mg, 10 mg, 20 mg; serenace drops 2 mg/ml; inj serenace, salidol 5 mg/ml).