In this article, we will discuss some Antiviral Drugs (Part-I). So, let’s get started.
Antiviral Drugs
Adefovir dipivoxil Lamivudine-resistant HBV infection. However, it has been widely replaced by tenofovir. Oral 10 mg/day can be administered up to the age of 5 years.
(Adesera, adfovir, adheb tab 10 mg).
Adenine arabinoside Neonatal HSV: 15-30 mg/kg/d given in single dose IV as a slow infusion during 12-24 hr for 10-21 days.
Indication: Herpes simplex infections.
(Vira A injection 200 mg per ml, Vira A ophthalmic ointment 3%).
Famciclovir It is recommended above 18 years of age. Herpes zoster: 500 mg q 8 hr for 7 days. Genital herpes simplex: 250 mg q 8hr for 7-10 days. Recurrent herpes labialis: 1.5 g single dose. Recurrent genital herpes: 250 mg b.d. for one year.
(Famtrex, microvir, penvir, virovir, famicimac tabs 250 mg, 500 mg).
Foscarnet CMV retinitis in patients with AIDS: 180 mg/kg/d q 8 hr IV slow infusion over 1 hour for 21 days (induction), then 90–120 mg/kg once daily as maintenance dose. Aciclovir-resistant HSV and herpes zoster in an immunocompromised
host: 120 mg/kg/d q 8 hr IV till resolution of infection or duration of 3 weeks.
Side Effects: Dizziness, hypertension, seizures, and dyselectrolytemia.
(Inj foscavir 500 mg, 1 g vials).