In this article, we will discuss Aleve ® (Overview). So, let’s get started.
Naproxen Owing to its strong anti-intlammatory activity and overall favourable toxicity profile it is commonly used NSAID in juvenile idiopathic arthritis in a dose of 10-20 mg/kg/day q 8-12 hr oral.
Mechanism of Action
Naproxen has analgesic, anti-inflammatory and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation, because naproxen is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Adult dose: 250-375 mg q 12 hr. There is no risk of cardiovascular complications.
C/I: Peptic ulcer disease salicylate or NSAID allergy, and advanced renal disease.
Indication: Musculoskeletal disorders, rheumatoid arthritis, osteoarthritis, migraine dysmenorrhea, gout.
(Artagen, naprosyn, nalyxan tab 250 mg; naprosyn tab 500 mg, xerobid tab 375 mg, naprosyn suspension 125 mg/5 ml).