In this article, we will discuss Bronchodilators-Dosage (Part-II). So, let’s get started.
Bronchodilators-Dosage
Ciclesonide Long-acting steroid for chronic asthma control 50-640 μg day. (Low dose-6-11 years: 80 μg/d, 12 years and older: 80–160 μg/d; medium dose-6-11 years: 80-160 μg/d, 12 years and older: >160-320 μg/d; high dose-6-11 years: >160 μg/d, 12 years and older: >320 μg/d).
Ciclesonide nasal spray for allergic rhinitis. 2-11 years: 50 μg 1-2 puffs daily, maximum 200 μg/d, 12 years and older: 2 puffs once daily, maximum 200 μg/d.
(MDI preparation is not available in india, Ciclohale rotacap 200 μg, 400 μg/cap, Nasal spray ciclospray, cinase, osonase 50 μg/puff, Combination inhaler Simplyone has ciclesonide 80 μg/160 μg and formeterol 4.5 μg per puff).
Doxofylline It is a new generation long-acting oral methyl xanthine derivative. It is given to children above 6 years in a dose of 6 mg/kg q 12 hr.
Adult dose: 400 mg single dose at night or twice a day.
(Doxiflo, synasma, befree, asmadox, freefil, theobed-D tab 400 mg, doxiba, synasma, doxiflo, amidox, fyline, freefil syr 100 mg/5 ml).
Fluticasone propionate Inhaled steroid for long-term asthma control is administered in a dose of 100–500 μg/d in two divided doses. Low dose-6-11 years: 100-200 μg/d, 12 years and older: 100-250 μg/d; medium dose-6-11 years: 200-500 μg/d, 12 years and older: 250-500 μg/d; high dose-6-11 years: >500 μg/d, 12 years and older: 500 μg/d.
Adult dose: 100-1000 μg/day.
(Flohale MDI 25 μg, 50 μg, 125 μg per dose/actuation; flohale rotacaps 100 μg, 250 μg per dose).
Fluticasone propionate plus salmeterol Starting dose 250 μg for moderate and 500 μg for severe asthma per day q 12 hr as per fluticasone component. Dose is adjusted as per level of asthma control. At present, not recommended for children below 4 years of age.
(Seroflo inhaler provides fluticasone 50 μg, 125 μg and 250 μg with salmeterol 25 μg) and seroflo rotacaps (fluticasone 100 μg, 250 μg and 500 μg with salmeterol 50 μg.); respules 0.5 mg and 1 mg/ml. Seretide accuhaler provides 50 μg salmeterol and fluticasone 50 μg, 250 μg, 500 μg; Forair, serobid, seroflo rotacaps 50 μg salmeterol per cap along with fluticasone 100 μg, 250 μg, 500 μg).
Formoterol fumarate It is a long-acting selective beta-2 adrenergic agonist. Always used in combination with inhaled
corticosteroids.
(Foracort inhaler and rotacaps contain 6 μg formoterol fumarate and 100 μg, 200 μg and 400 μg budenoside per dose).