In this article, we will discuss Miscellaneous Antimicrobials-Dosage (Part-III). So, let’s get started.
Tigecycline It is a derivative of minocycline belonging to a new class of antibiotics called glycylcyclines. 1.5 mg/kg as single dose (maximum 100 mg). Maintenance 1 mg/kg/day as IV infusion over 30-60 min. Effective against MRSA, Gram-negative MDR, Acinetobacter ESBL, and carbapenem-resistant S. aureus. Safety not established in children.
Adult dose: 100 mg as a single dose or 50 mg q 12 hr IV.
Caution: Hepatotoxicity.
(Inj tiganex, tygacil, tigebax, tigilyn, tigimax, zutig, egytig, divercil 50 mg).
Tetracycline hydrochloride 25–50 mg/kg/day q 6 hr oral. Avoid in children below 8 years. There is no place for tetracycline syrup in pediatric therapy. Avoid administration with food.
Adult dose: 1-2 gm daily in 4 divided doses.
C/I: <8 yr age; SLE, and hypersensitivity.
Side Effects: GI disturbances, Clostridium difficile-induced diarrhea (pseudomembranous colitis), and candidiasis.
(Tetracyl, arcycline, lupiterra, achromycin (tetracycline) caps 250 mg, 500 mg; terramycin (oxytetracycline) cap 250 mg: inj achromycin 250 mg and 500 mg IV, inj achromycin 100 mg IM).
Vancomycin hydrochloride 40 mg/kg/day q 6 hr by infusion over 60 minutes or longer. 60 mg/kg/day q 6 hr for CNS infection. In pseudomembranous colitis, 40-50 mg/kg/day q 6-8 hr oral.
Adult dose: 500 mg q 6 hr or 1 g q 12 hr.
Caution: Flushing of face and neck (“red man” syndrome), if infusion is given rapidly. Give slow IV infusion over one hour.
Side Effects: Anaphylaxis, ototoxicity, thrombocytopenia, hypotension,
renal dysfunction.
Indication: Pencillinase-resistant staphylococcal and pneumococcal
infections, and antibiotic-associated diarrhea.
(Inj forstaf, vancogen, vancocin, vancorin, vancotech, vanlid, vancomate, vanconis, vanking, valcosa 500 mg per vial; vanco-
CP, vansafe CP, vantox CP 500 mg, 1 g in 10 ml vials; vancocin CP cap, 125 mg).