In this article, we will discuss Sulphas (Antibiotics)-Dosage. So, let’s get started.
Sulphas
Sulfonamides 100-150 mg/kg/day q 8 hr oral. For prophylaxis against meningococcal infection: 500 mg every 24 hr for 2 days for infants below 1 year and 500 mg every 12 hr for 2 days for older children. Triple sulfa or sulfasoxazole should be preferred because they are short acting and least toxic.
Adult dose: 500 mg q 6 hr (maximum 46 g/day).
Adverse effects: Hypersensitivity reactions, such as skin rash, Stevens-Johnson syndrome, vasculitis, serum sickness, drug fever, anaphylaxis, and angioedema.
C/I: Hypersensitivity to sulfa drugs.
(Sulphamethizole, sulfasoxazole, triple sulpha, orisul tab 500 mg).
Trimethoprim-sulfamethoxazole (co-trimoxazole) 5-8 mg/kg of TMP or 25-50 mg/kg of SMZ/day q 12 hr oral or IV. 10 mg/kg/day q 12 hr of TMP for typhoid fever and 20 mg/kg/day of TMP q 6-8 hr for Preumocystis jirovecii infection. For prophylacis against Pneumocystis carinii, 5 mg/kg of TMP either single dose or two divided doses daily for 3 consecutive days in a week or every alternate day. Single dose 1-3 mg/kg/day of TMP for UTI prophylaxis.
Adult dose: 2 tabs (80 mg/400 mg strength) twice daily; in severe infections give 3 tabs twice daily.
C/I: Age <6 weeks; hypersensitivity to sulfa, G-6-PD deficiency.
(Septran, bactrim, colizole, supristol, methoxaprim, oriprim, ciplin, sevoprim tab TMP 80 mg, SMZ 400 mg, cotrimoxazole-DS, sumetrol-DS 400 mg or double strength tab; septran, bactrim, sevoprim, pediatric tab TMP 20 mg, SMZ 100 mg; susp TMP 40 mg and SMZ 200 mg per 5 ml; TMP 160 mg and SMZ 800 mg per 3 ml ampoule for IM or IV).