Antibiotics Carbapenems Pharmacology Physiotherapy

Carbapenems (Dosage)

In this article we will discuss Carbapenems (Dosage)

In this article, we will discuss Carbapenems (Dosage). So, let’s get started.


They are structurally similar to penicillins but the sulfur atom in position 1 has been replaced with a carbon atom. They are effective against beta-lactamase producing enterobacteriaceae like Klebsiella pneumoniae, E. coli, Citrobacter sp, Acinobacter sp; Pseudomonas aeruginosa and Alcaligenes sp. They are not effective against MRSA (methicillin-resistant Staphylococcus aureus) and NDM-1 (New Delhi metallo-beta-lactamase 1) strains. They can be administered only intravenously.


Adult dose: 500 mg IV 8 hourly, safety and efficacy in children not studied.

(Carbador, doribax, dorikem, inarem in 500 mg vial).


Indication: Same as meropenem, 3 months-13 yr: 15 mg/kg/dose IV b.d., adult dose 1 god. IV.

Side effect: DRESS, pruritus, diarrhea, vomiting, nausea.

(Forstal, invanz, mypenem, zivatar in 1 g vial).

Faropenem Oral formulation is available, but it is not yet approved for use in children.

Adult dose: 150-300 mg t.d.s.

SE: Nausea, vomiting, diarrhea, skin rash, sweating, headache, myalgias.

(Duonem, farobact, faronac, farozet, orpenem tabs 150 mg, 200 mg, 300 mg)

Imipenem/cilastatin 60-100 mg/kg/day of imipenem q6 hr IV. Broad spectrum beta-lactam antibiotic for aerobic and anaerobic Gram-positive and Gram-negative bacteria.

Caution: Use with caution in children with epilepsy.

Adult dose: 250 mg-1 g IV q 6-8 hr; maximum daily dose 2 g.

Indication: Drug of choice for extended spectrum beta-lactamase producing microorganisms (ESBL).

(Imicrit, carbinem, cilaxter, cilanem, imecila, zienam, 1-nem contains 250 mg or 500 mg each of imipenam and cilastatin).

Meropenem 60 mg/kg/day q 8 hr IV. For neonatal sepsis, 20 mg/kg/dose q 12 hr, meningitis 40 mg/kg/dose q 8 hr.

Adult dose: 500 mg-1 g q 8 hr slow IV infusion.

Indication: Drug of choice for extended spectrum beta-lactamase producing microorganisms (ESBL).

(Inj. merobact, mero, merocrit, penam, aeropen, meronem, esblanem, romen 250 mg, 500 mg, 1000 mg vials)

The complete list of beta-lactamase resistant antibiotics includes 3rd and 4th generation cephalosporins, carbapenems, aztreonam, beta-lactamase-resistant penicillins (methicillin, naficillin, oxacillin,
cloxacillin, dicloxacillin) and combo penicillins (containing clavulanic acid or sulbactam).

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