In this article, we will discuss the Pathogenesis of Biliary Colic. So, let’s get started.
Pathogenesis
Two important factors in pathogenesis of acute biliary colic are obstruction with superadded or concomittant infection. Obstruction leads to dilatation of the biliary system proximal to obstruction resulting in rise in intraluminal pressure followed by or concomittant infection of the stagnant bile. Infection or acute cholangitis causing acute biliary colic can occur in the absence of obstruction. Portal vein is the most significant pathway of bacterial colonisation of biliary system. Another route is invasion of biliary system directly from the gut through the sphincter of oddi or through the biliary enteric communications.
The fever and chills accompanying acute biliary colic indicate acute cholangitis due to bacteremia. As a result of obstruction, there may be regurgitation of bacteria from the bile into hepatic venous system and is directly proportional to biliary pressure.