Causes of Thrombocytopenia

In this article, we will discuss various Causes of Thrombocytopenia. So, let’s get started.

Causes

1. Impaired production

1a. Generalised bone marrow failure

  • Aplastic anemia
  • Megaloblastic anemia
  • Leukemia
  • Myeloma
  • Myelofibrosis
  • Marrow infiltration by solid tumors or others (myelophthisic process)
  • Fanconi anemia

1b. Selective reduction of platelets

  • Drugs, physical agents (irradiation)
  • Chemicals
  • Viral infections

2. Excessive destruction/consumption

2a. Immune

  • Autoimmune thrombocytopenic purpura
  • Secondary immune thrombocytopenia (CLL, SLE, viral infection,e.g. hepatitis C and HIV drugs)
  • Autoimmune neonatal thrombocytopenia

2b. Coagulation

  • Disseminated intravascular coagulation
  • Thrombotic Thrombocytopenic Purpura
  • Hemolytic-uremic syndrome
  • Heparin-induced

2c. Mechanical microangiopathy

  • Valvular disorders

2d. Increased sequestration by spleen

  • Splenomegaly due to any cause, e.g. infective, congestive, infiltrative, neoplastic, etc.

2e. Hypersplenism, e.g. portal hypertension, myeloproliferative disease, lymphoma

2f. Dilutional loss and gestational

2g. Massive transfusion of stored blood (post transfusion purpura)

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