In this article, we will discuss various Causes of Thrombocytopenia. So, let’s get started.
Causes
1. Impaired production
1a. Generalised bone marrow failure
- Aplastic anemia
- Megaloblastic anemia
- Leukemia
- Myeloma
- Myelofibrosis
- Marrow infiltration by solid tumors or others (myelophthisic process)
- Fanconi anemia
1b. Selective reduction of platelets
- Drugs, physical agents (irradiation)
- Chemicals
- Viral infections
2. Excessive destruction/consumption
2a. Immune
- Autoimmune thrombocytopenic purpura
- Secondary immune thrombocytopenia (CLL, SLE, viral infection,e.g. hepatitis C and HIV drugs)
- Autoimmune neonatal thrombocytopenia
2b. Coagulation
- Disseminated intravascular coagulation
- Thrombotic Thrombocytopenic Purpura
- Hemolytic-uremic syndrome
- Heparin-induced
2c. Mechanical microangiopathy
- Valvular disorders
2d. Increased sequestration by spleen
- Splenomegaly due to any cause, e.g. infective, congestive, infiltrative, neoplastic, etc.
2e. Hypersplenism, e.g. portal hypertension, myeloproliferative disease, lymphoma
2f. Dilutional loss and gestational
2g. Massive transfusion of stored blood (post transfusion purpura)