Predisposing Factors/Conditions to Sepsis or Septic Shock

In this article, we will discuss the Predisposing Factors/Conditions to Sepsis or Septic Shock. So, let’s get started.

Sepsis or systemic inflammatory response syndrome (SIRS): In a patient with proven or suspected microbial infection, the presence of two of the following 4 symptoms and signs constitutes sepsis or SIRS.

  • Oral temperature of >38°C or <36°C
  • Respiratory rate >24/min or PaCO2 <32 mmHg
  • Heart rate >90/min
  • Leucocyte count >12000/μl or 4000/μl or >10% band forms.

Septic Shock: It is defined as sepsis with hypotension (SBP <90mmHg or fall of SBP >40mmHg below the patient’s normal BP) for at least one hour despite adequate fluid replacement, blood lactate level more than 2 mmol/L and need of vasopressors to maintain SBP >90 mmHg.

Predisposing Factors

  • Immunocompromised state, e.g. Diabetes mellitus, AIDS, cytotoxic and steroid use
  • Malignancies, e.g. leukemia, lymphoma
  • Liver cirrhosis (portosystemic infection)
  • Extensive burns
  • Neutropenia
  • Implants, prosthesis, IV drug abuse
  • Antibiotic abuse
  • Invasive procedures
  • Malnutrition
  • Rupture of hollow viscus
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