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Aplastic anemia Hematology Physiotherapy

Causes of Aplastic Anemia

In this article we will discuss various Causes of Aplastic Anemia.

In this article, we will discuss various Causes of Aplastic Anemia. So, let’s get started.

Causes

Inherited

  • Fanconi’s anemia
  • Diamond-Blackfen syndrome
  • Reticular dysgenesis (dyskeratosis congenita)

Acquired

A. Idiopathic (primary) probably autoimmune

B. Secondary

i. Diseases, e.g. SLE

ii. Drugs (direct cytotoxicity, idiosyncratic reactions)

  • Cytotoxic drugs, e.g. alkylating agents, antimetabolites etc.
  • Antibiotics, e.g. sulphonamides, chloramphenicol
  • Antirheumatic drugs, e.g. penicillamine, gold, phenylbutazone, indomethacin, ibuprofen
  • Antithyroid drugs
  • Anticonvulsants (hydantoins, carbamazepine etc)
  • Immunosuppressants, e.g. azathioprine, busulphan, cyclophosphamide, chlorambucil, vinblastine, 6-mercaptopurine

iii. Chemicals

  • Heavy metals, e.g. gold, arsenic, bismuth, mercury
  • Industrial solvents
  • Benzene-containing solvents, e.g. kerosene, carbontetrachloride
  • Insecticide, e.g. organophosphorus, carbamates, DDT (chlorinated hydrocarbon)

iv. Irradiation

  • Ionising radiation (radiodiagnosis, radiotherapy, nuclear power station)

v. Viruses

  • Hepatitis viruses (post-hepatitis)
  • Epstein-Barr viruses, parvovirus B19 (aplastic crisis)
  • HIV

vi. Pregnancy

vii. Paroxysmal nocturnal hemoglobinuria

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