In this article we will discuss Analytical and clinical validation of liquid biopsy assays for minimal residual disease detection after curative treatment
Tag: Oncology
CAR-T therapy has transformed treatment for certain blood cancers. However, solid tumours present greater challenges. The immunosuppressive microenvironment and limited T-cell trafficking reduce effectiveness. Researchers therefore develop multiple strategies to overcome these barriers. Solid tumours create a hostile local environment. Dense stroma, low oxygen levels, and inhibitory molecules restrict CAR-T cell function. Regulatory immune cells […]
Study Reveals Gaps in Oncology Guideline Adherence Across Tertiary Cancer Centers Researchers examined adherence to oncology patient care guidelines in major tertiary cancer centers. They compared national standards from ICMR and NCI-India with international ones from ASCO, ESMO, and NCCN. The analysis focused on how closely doctors followed these guidelines. It also measured links to […]
Oral cancer remains a major health concern in India. Tobacco use drives a large share of cases. Many patients reach hospitals only after the disease has advanced. Diagnostic delays play a critical role in this pattern. Patients often wait long before seeking care. They also face further delays after contacting the health system. As a […]
Neoadjuvant therapy aims to shrink tumors before surgery. However, residual disease often persists. These remaining cells can drive later relapse. Researchers therefore examine residual populations closely. Longitudinal multi-omics profiling tracks molecular changes over time. Scientists collect samples before treatment and after therapy. They then analyze DNA, RNA, proteins and epigenetic marks together. This integrated approach […]
PD-L1 expression shows clear heterogeneity across solid tumours. Researchers actively examine this variation. They measure its direct impact on immunotherapy results. Tumours express PD-L1 at different levels. Levels also change within the same tumour. Pathologists observe spatial differences. They further note temporal changes during treatment. Anatomical site strongly influences expression patterns. Lung cancers often display […]