Precipitating Factors and Differential Diagnosis of Myxoedema Coma

In this article, we will discuss the Precipitating Factors and Differential Diagnosis of Myxoedema Coma. So, let’s get started.

Precipitating Factors

The factors that push the patient of hypothyroidism into myxoedema coma are given below:

  • Infection, e.g. pneumonia
  • Exposure to cold
  • Hypoventilation
  • Hypoglycemia
  • Dilutional hyponatremia
  • Trauma
  • GI bleeding
  • Stroke (CVA)
  • CNS depressants, e.g. tranquillisers, sedatives and antidepressants
  • Cardiovascular disease (e.g. CHF), myocardial infarction
  • Respiratory disease (infection, COPD)

Hypoventilation leading to hypoxia and hypercapnia plays a major role in pathogenesis. Hypoglycemia and dilutional hyponatremia also contribute to the development of myxoedema coma.

Differential Diagnosis

The conditions which are associated with coma and hypothermia may mimic myxoedema coma. These include:

1. Brainstem infarction in older persons may lead to both coma and hypothermia

2. Hypothermia due to any cause and renal failure may itself induce physiological changes simulating myxoedema such as delayed relaxation of deep tendon reflexes. Coma is due to hypothermia and renal failure.


Symptoms of Hypothyroidism or Low Thyroid Levels

In this blog we will discuss about the symptoms that indicates that your thyroid level has gone below normal values, so that you may take adequate measures at the right time. Generally womens suffer more from hypothyroidism than men.



Weight gain

Swelling at base of neck


Hair loss



Dry Skin


Change in menstrual cycle usually longer and heavier periods, menorrhagia


Muscle Aches

Brittle Nails



Brain fog

Sleep Disturbances

Cold Intolerance

Puffy face

If you have some of the symptoms, please make sure you test your T3,T4,FT3,FT4,T3RUand TSH levels (Thyroid Hormones).These test along with some other tests helps in diagnosis of Hypothyroidism.

In the next blog we will discuss about causes, diagnosis and treatment of Hypothyroidism

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