Oxaprozin Pharmacology Physiotherapy

Oxaprozin (Metabolism)

In this article we will discuss Oxaprozin (Metabolism)

In this article, we will discuss Oxaprozin (Metabolism). So, let’s get started.

Oxaprozin (Metabolism)

Several oxaprozin metabolites have been identified in human urine or feces.
Oxaprozin is primarily metabolized by the liver, by both microsomal oxidation (65%) and glucuronic acid conjugation (35%). Ester and ether glucuronide are the major conjugated metabolites of oxaprozin. On chronic dosing, metabolites do not accumulate in the plasma of patients with normal renal function. Concentrations of the metabolites in plasma are very low. Oxaprozin’s metabolites do not have significant pharmacologic activity. The major ester and ether glucuronide conjugated metabolites have been evaluated along with oxaprozin in receptor binding studies and in vivo animal models and have demonstrated no activity. A small amount (<5%) of active phenolic metabolites are produced, but the contribution to overall activity is limited.

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