In this article, we will discuss Bleomycin and Pediatric Population (Pharmacokinetics). So, let’s get started.
Bleomycin and Pediatric Population (Pharmacokinetics)
Children of less than 3 years of age have higher total body clearance than in adults,
71 mL/min/m2 versus 51 mL/min/m2, respectively, following intravenous bolus
administration. Children of more than 8 years of age have comparable clearance as in adults.
In children with normal renal function, plasma concentrations of bleomycin decline
biexponentially as in adults. The volume of distribution and terminal half-life of
bleomycin in children appears comparable to that in adults