In this article, we will discuss Methylene Blue (Dosage). So, let’s get started.
Methylene blue (methylthioninium chloride). It is a thiazine dye and works by converting the ferric iron in hemoglobin to ferrous iron. It is first reduced to leucomethylene blue, which reduces heme group from methemoglobin to hemoglobin. It is given in a dose of 1 mg/kg IV over 5-30 minutes. If methemoglobin level remains greater than 30%, a repeat dose can be given after one hour. Along with dihydroartemisinin-piperaquine, methylene blue in an oral dose of 15 mg/kg/d for 3 days, is useful to treat artemesinin-resistant malaria and
prevent transmission of gametocytes of P. falciparum from humans to mosquitoes.
Adult dose: 50 mg oral or IV stat.
Indication: Methemoglobinemia, falciparum malaria and ifosfamide
C/I: G6PD deficiency.
Caution: Do not refrigerate or expose to tight.
Side Effects: Headache, vomiting, excessive release of serotonin, confusion, shortness of breath, elevation of blood pressure, bluish or greenish discoloration of urine and sweat.
(Provayblue 50 mg 10 ml and blueject 100 mg/10 ml vials. Dilute in 50 ml of 5% dextrose in water).