In this article, we will discuss CELEBREX ™ (Celecoxib). So, let’s get started.

Celecoxib Selective COX-2 inhibitor. It should be used in patients at high risk of peptic ulcer, perforation or gastrointestinal bleeds. It is the only FDA approved selective COX-2 inhibitor recommended for use in juvenile idiopathic arthritis. CELEBREX (celecoxib) is chemically designated as 4-15-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl) benzenesulfonamide and is a diaryl substituted pyrazole.

The empirical formula for celecoxib is C17H14F3N3O2S, and the molecular weight is 381.38.

Mechanism of Action

CELEBREX is a nonsteroidal anti-inflammatory drug that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, CELEBREX does not inhibit the cyclooxygenase-I (COX-1) isoenzyme.


Children: 10-25 kg: 50 mg b.d., >25 kg: 100 mg b.d.
Adult dose: 200 mg/day in one or two divided doses.

(Celact, celcib, celib, cobix, colcibra
caps 100 mg and 200 mg).


CELEBREX is indicated:
1) For relief of the signs and symptoms of osteoarthritis.
2) For relief of the signs and symptoms of rheumatoid arthritis in adults.


CELEBREX is contraindicated in patients with known hypersensitivity to celecoxib. CELEBREX should not be given to patients who have demonstrated allergic-type reactions to sulfonamides. CELEBREX should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.

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