In this article, we will discuss Aminoglycosides (Dosage). So, let’s get started.
Aminoglycosides
(Adjust the dose in patients with renal failure).
Amikacin sulfate 15-20 mg/kg/day IV, higher dose may be considered in cystic fibrosis patients. Intravenous infusion to
be given over 1 hour.
Adult dose: 15 mg/kg/day q 12 hr (maximum 1.5 g/day). For drug-resistant TB, 15 mg/kg single daily dose IM 5-7 days
per week.
(Inj amicin, alfakim, amistar, biocin, ivimicin, amitax, mikacin, novacin vials 100 mg, 250 mg and 500 mg).
Gentamicin sulfate 5.0-7.5 mg/kg/day IM, cystic fibrosis 7-10 mg/kg/day IV q 8-12 hr. In ambulatory cases, 4 mg/kg IM single dose per day is effective.
Adult dose: 250 mg per day q 8-12 hr IM, IV.
C/I: Myasthenia gravis, previous toxic reaction to aminoglycoside.
(Inj genticyn, biogaracin, lyramycin, garamycin, genkind, gentasporin, ingen, lupigenta 1.5 ml, 2 ml ampoules 40 mg/ml, 10 mg/ml).
Kanamycin sulfate 15-30 mg/kg/day q 8-12 hr IM, IV given over 30-60 minutes. MDR tuberculosis 15 mg/kg/day. In some cases, dose up to 30 mg/kg/day has been recommended.
Adult dose: 0.5-1 g daily q 12 hr, maximum 1.5 g/day.
(Inj kancin 500 mg, 1 g per vial;inj efficin, kanamac, neokanyn 500 mg, 750 mg, 1 g per vial).
Netilmicin sulfate Children: 5.0-7.5 mg/kg/day q 8-12 hr IM or IV. Infants: 7.5-10 mg/kg/day, <1 week age: 3 mg/kg 9 12 hr.
Adult dose: Non-life-threatening infection: 4-6 mg/kg/d; life-threatening infection: 7.5 mg/kg/d.
(Inj netromycin 10 mg, 25 mg, 50 mg, 100 mg per ml amp; inj neticin 200 mg, 300 mg vials; inj netspan 50 mg, 300 mg vials).
Streptomycin sulfate 20-40 mg/kg/day q 12 hr or single dose IM.
Adult dose: 0.75-1 g daily IM, maximum dose 1 g/day.
C/I: Hypersensitivity reaction to the drug, ear disease.
(Inj ambistryn-S, cipstryn, streptomac, isos 0.75 g, 1.0 g vials).
Tobramycin 6.0-7.5 mg/kg/day IV, IM q 8-12 hr.
Adult dose: 3-5 mg/kg/day q 6-8 hr.
(Inj tobacin, tobraneg, tocin 20 mg, 40 mg, 80 mg in 2 ml vials).