Aminoglycosides (Dosage)

In this article, we will discuss Aminoglycosides (Dosage). So, let’s get started.

Aminoglycosides

(Adjust the dose in patients with renal failure).

Amikacin sulfate 15-20 mg/kg/day IV, higher dose may be considered in cystic fibrosis patients. Intravenous infusion to
be given over 1 hour.

Adult dose: 15 mg/kg/day q 12 hr (maximum 1.5 g/day). For drug-resistant TB, 15 mg/kg single daily dose IM 5-7 days
per week.

(Inj amicin, alfakim, amistar, biocin, ivimicin, amitax, mikacin, novacin vials 100 mg, 250 mg and 500 mg).

Gentamicin sulfate 5.0-7.5 mg/kg/day IM, cystic fibrosis 7-10 mg/kg/day IV q 8-12 hr. In ambulatory cases, 4 mg/kg IM single dose per day is effective.

Adult dose: 250 mg per day q 8-12 hr IM, IV.

C/I: Myasthenia gravis, previous toxic reaction to aminoglycoside.

(Inj genticyn, biogaracin, lyramycin, garamycin, genkind, gentasporin, ingen, lupigenta 1.5 ml, 2 ml ampoules 40 mg/ml, 10 mg/ml).

Kanamycin sulfate 15-30 mg/kg/day q 8-12 hr IM, IV given over 30-60 minutes. MDR tuberculosis 15 mg/kg/day. In some cases, dose up to 30 mg/kg/day has been recommended.

Adult dose: 0.5-1 g daily q 12 hr, maximum 1.5 g/day.

(Inj kancin 500 mg, 1 g per vial;inj efficin, kanamac, neokanyn 500 mg, 750 mg, 1 g per vial).

Netilmicin sulfate Children: 5.0-7.5 mg/kg/day q 8-12 hr IM or IV. Infants: 7.5-10 mg/kg/day, <1 week age: 3 mg/kg 9 12 hr.

Adult dose: Non-life-threatening infection: 4-6 mg/kg/d; life-threatening infection: 7.5 mg/kg/d.

(Inj netromycin 10 mg, 25 mg, 50 mg, 100 mg per ml amp; inj neticin 200 mg, 300 mg vials; inj netspan 50 mg, 300 mg vials).

Streptomycin sulfate 20-40 mg/kg/day q 12 hr or single dose IM.

Adult dose: 0.75-1 g daily IM, maximum dose 1 g/day.

C/I: Hypersensitivity reaction to the drug, ear disease.

(Inj ambistryn-S, cipstryn, streptomac, isos 0.75 g, 1.0 g vials).

Tobramycin 6.0-7.5 mg/kg/day IV, IM q 8-12 hr.

Adult dose: 3-5 mg/kg/day q 6-8 hr.

(Inj tobacin, tobraneg, tocin 20 mg, 40 mg, 80 mg in 2 ml vials).

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