Pathology of Acute Nephritic Syndrome

In this article, we will discuss the Pathology of Acute Nephritic Syndrome. So, let’s get started.

Pathology

The hallmark of acute nephritic syndrome is glomerular inflammation (hypercellularity) and the classical pathologic correlation of the nephritic syndrome is proliferative glomerulonephritis. The proliferation of glomerular cells is due to infiltration of the glomerular tuft by neutrophils and monocytes with subsequent proliferation of endothelial and mesangial cells (endocapillary proliferation). In most severe form, nephritic syndrome is associated with acute inflammation of most of the glomeruli (more than 50%), e.g. acute diffuse proliferative glomerulonephritis. In less severe form, fewer than 50% of the glomeruli may be involved, i.e. focal proliferative glomerulonephritis. In its mildest form, cellular proliferation is just confined to the mesangium, i.e. mesangioproliferative glomerulonephritis.

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