Role of Cancer-Associated Fibroblasts and Extracellular Matrix Remodeling in Promoting Therapy Resistance: Integrated Molecular and Histopathological Analysis Cancer-associated fibroblasts play a central role in the tumor microenvironment. These cells actively support tumor growth and progression. At the same time, they remodel the extracellular matrix. This remodeling creates physical and biochemical barriers that limit drug delivery. […]
Category: Oncology
Intégration de la radiomique et des données génomiques pour prédire les résultats des traitements La radiomique analyse les images médicales. Elle extrait de nombreuses caractéristiques quantitatives. Parallèlement, la génomique étudie les altérations moléculaires des tumeurs. Aujourd’hui, les chercheurs combinent ces deux approches. Cette intégration améliore la prédiction des résultats thérapeutiques. Elle concerne surtout les tumeurs […]
Biomarqueurs prédictifs de réponse et de résistance à la chimiothérapie à base de pémétrexed dans le mésothéliome pleural Le mésothéliome pleural malin reste un cancer agressif. Le pémétrexed associé à un sel de platine constitue depuis longtemps un traitement standard. Cependant, la réponse à cette chimiothérapie varie fortement selon les patients. Identifier des biomarqueurs prédictifs […]
Molecular Glues as a New Modality: Case Studies in Cereblon-Based Degraders for Hematologic Cancers Molecular glues represent an emerging class of therapeutic agents. These small molecules stabilize interactions between proteins. In doing so, they often trigger the degradation of disease-relevant targets. Unlike traditional inhibitors, molecular glues do not simply block protein function. Instead, they promote […]
Retifanlimab: A PD-1 Inhibitor for Rare and Difficult Cancers Retifanlimab is a modern immunotherapy drug. Doctors know it better by its brand name, Zynyz. Incyte Corporation developed this medication. It belongs to the class of PD-1 inhibitors. These drugs help the immune system fight cancer more effectively. How Retifanlimab Works Cancer cells often hide from […]
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Understanding Neoplasia
Understanding Neoplasia Neoplasia refers to the abnormal growth of cells in the body. This growth can be benign or malignant. Neoplasia occurs when cells divide and multiply uncontrollably. Types of Neoplasia: Benign Neoplasia: Non-cancerous growths that do not spread to other parts of the body. Malignant Neoplasia: Cancerous growths that can invade surrounding tissues and […]