Etiology of Adrenal Crisis/Acute Adrenal Insufficiency

In this article, we will discuss the Etiology of Adrenal Crisis/Acute Adrenal Insufficiency. So, let’s get started.


Adrenal Causes

  • Sudden precipitation of Addison’s disease of adrenal origin
  • Bilateral adrenal hemorrhage (anticoagulant therapy or coagulation/bleeding disorders)
  • Bilateral adrenal thrombosis, e.g. antiphospholipid syndrome
  • Adrenal necrosis due to sepsis or septicemia (Water-house-Friderichsen syndrome)

Pituitary Causes

  • Postpartum pituitary necrosis (Sheehan’s syndrome)
  • Necrosis or bleeding into pituitary microadenoma
  • Head trauma
  • Lesions of pituitary stalk
  • Pituitary or adrenal surgery for Cushing’s syndrome

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