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Antiarrhythmics Arrhythmias Cardiology Medicine Physiotherapy

Vaughan William’s Classification of Antiarrhythmics

In this article we will discuss the Vaughan William’s Classification of Antiarrhythmics

In this article, we will discuss the Vaughan William’s Classification of Anti-arrhythmics. So, let’s get started.

Vaughan William’s Classification

Class I: They block fast Na+ channels

A. Prolong action potential duration

  • Quinidine, procainamide, ajmaline disopyramide

B. Shorten duration of action potential

  • Lidocaine, phenytoin, tocainide, mexiletine

C. No effect on action potential, slow the conduction

  • Flecainide, encainide, propafenone, moricizine

Class II: Beta-blockers

  • Propranolol, metoprolol, atenolol, timolol, sotalol

Class III: They block K+ channel

  • Amiodarone, sotalol, bretylium, ibutilide, dofetilide, dronedarone, vernakalant

Class IV: Ca++ channel blockers

  • Verapamil, diltiazem, adenosine, digoxin, magnesium sulfate

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