In this article, we will discuss the Vaughan William’s Classification of Anti-arrhythmics. So, let’s get started.
Vaughan William’s Classification
Class I: They block fast Na+ channels
A. Prolong action potential duration
- Quinidine, procainamide, ajmaline disopyramide
B. Shorten duration of action potential
- Lidocaine, phenytoin, tocainide, mexiletine
C. No effect on action potential, slow the conduction
- Flecainide, encainide, propafenone, moricizine
Class II: Beta-blockers
- Propranolol, metoprolol, atenolol, timolol, sotalol
Class III: They block K+ channel
- Amiodarone, sotalol, bretylium, ibutilide, dofetilide, dronedarone, vernakalant
Class IV: Ca++ channel blockers
- Verapamil, diltiazem, adenosine, digoxin, magnesium sulfate