Vaughan William’s Classification of Antiarrhythmics

In this article, we will discuss the Vaughan William’s Classification of Anti-arrhythmics. So, let’s get started.

Vaughan William’s Classification

Class I: They block fast Na+ channels

A. Prolong action potential duration

  • Quinidine, procainamide, ajmaline disopyramide

B. Shorten duration of action potential

  • Lidocaine, phenytoin, tocainide, mexiletine

C. No effect on action potential, slow the conduction

  • Flecainide, encainide, propafenone, moricizine

Class II: Beta-blockers

  • Propranolol, metoprolol, atenolol, timolol, sotalol

Class III: They block K+ channel

  • Amiodarone, sotalol, bretylium, ibutilide, dofetilide, dronedarone, vernakalant

Class IV: Ca++ channel blockers

  • Verapamil, diltiazem, adenosine, digoxin, magnesium sulfate

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