Pathogenesis of Rabies

In this article, we will discuss the Pathogenesis of Rabies So, let’s get started.


Th incubation period of rabies is between 20-90 days but it is extended up to 1 year in rare cases. Following inoculation of the virus by a dog bite, cat bite, or monkey bite, etc the virus binds to neuromuscular junction and multiplies in the muscles, then it spreads centrifugally along the peripheral nerves to the spinal cord and brain. Once the virus enters the CNS, it rapidly disseminates to other regions of the CNS along with neuroanatomic connections. Neurons are mainly attacked by the virus. After CNS infection becomes established it spreads centrifugally along the sensory and autonomic nerves to the salivary glands, eye, skin, and other organs.

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