Hypertrichosis or Werewolf Syndrome

What is Hypertrichosis?

In this article we will discuss about What is Hypertrichosis or Werewolf syndrome

In this article we will discuss about What is Hypertrichosis? So let’s get started.


It is also known as “Werewolf syndrome” characterized by abnormal hair growth all across the body. It is an extremely rare disease. It is of following types:

Congenital Hypertrichosis lanuginosa

Congenital Generalized Hypertrichosis

Congenital Localised Hypertrichosis

Congenital Hypertrichosis Terminalis

Congenital Circumscribed Hypertrichosis

Congenital Nevoid Hypertrichosis

Acquired Hypertrichosis lanuginosa

Acquired Generalized Hypertrichosis

Acquired Localised Hypertrichosis

Acquired Patterened Hypertrichosis

Congenital Hypertrichosis lanuginosa is caused due to paracentric inversion mutation of q22 band of chromosome 8. It is of autosomal dominant form.

Congenital Generalized Hypertrichosis is linked to chromosome Xq24-27.1.

Congenital Hypertrichosis Terminalis is caused due to mutaion in chromosome 17. It is also associated with mutation in gene MAP2K6.

Medications like cyclosporine, phenytoin, psoralen, minoxidil, diazoxide, acetazolamide, streptomycin are responsible to cause Hypertrichosis.

Symptoms include excessive hair growth in generalized it is present all over the body, in localised and circumscribed it is present in specific and restricted area. In Patterened hair growth occurs in a distinct pattern and based on hair type it can be lanugo, vellus or terminal.

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