Adverse Events in Pediatric and Adolescent Populations from Short-Course Corticosteroids Doctors often prescribe short-course corticosteroids to children and teens. These drugs treat asthma attacks, croup, allergic reactions, and acute inflammation. Treatment usually lasts 3 to 7 days. However, even brief use can cause side effects. Children and adolescents react differently than adults. Their growing bodies […]
Category: Physiotherapy
Corticosteroid resistance poses a major challenge in chronic inflammatory conditions. Researchers observe it frequently in severe asthma, COPD, rheumatoid arthritis, and other diseases. Glucocorticoids normally bind to the glucocorticoid receptor (GR). This complex moves to the nucleus. There, it suppresses inflammatory genes through histone deacetylase-2 (HDAC2) recruitment. Moreover, it activates anti-inflammatory genes. In resistant cases, […]
Analyze antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease (MASLD/MASH) MASLD affects millions worldwide. It often progresses to MASH with fibrosis. Antifibrotic therapies target scar tissue buildup. They aim to reverse liver damage. Researchers focus on drugs that halt or reduce fibrosis. Recent approvals mark progress. Resmetirom leads the pack. This THR-β agonist gained FDA […]
Gastric intestinal metaplasia often progresses silently. Doctors monitor it closely to prevent stomach cancer. This condition replaces normal stomach lining with intestinal-type cells. Moreover, it raises cancer risk over time. Helicobacter pylori infection drives most cases. Eradication of this bacterium slows progression significantly. However, metaplasia sometimes persists even after treatment. Therefore, ongoing surveillance becomes essential. […]
Immunosenescence describes the gradual decline of the immune system with age. It affects both innate and adaptive immunity. This process weakens protection against infections and diseases. The immune system changes profoundly as people grow older. Thymic involution occurs first. The thymus shrinks and produces fewer naive T cells. Consequently, the body relies more on memory […]
Neoantigen vaccine design targets cancer cells precisely. Researchers create personalized vaccines for each patient. These vaccines use unique mutations in tumor cells. The process starts with tumor sequencing. Doctors collect samples from the patient’s tumor and normal tissue. Next, they perform whole-exome sequencing. This identifies mutations that create new proteins. Bioinformatics tools analyze the data. […]