In this article we will discuss about Danbolt-Closs Syndrome. So let’s get started.
Also known as Acrodermatitis Enteropathica. It is an Autosomal Recessive Metabolic Disorder that mainly affects the zinc uptake through the inner lining of bowel(the mucous membrane) characterized by alopecia, acral dermatitis, diarrhoea, steatorrhea and pustular eruptions on face and around body orifices. It is caused due to mutation in SLC39A4 encoding ZIP4 Transporter. It is estimated to occur in 1 in 500,000 live births. Zinc deficiency causes this disease and it may be due to decreased absorption, increased consumption or increased excretion of zinc.